Reviews from the Clayden Group

315. Screw Sense and Screw Sensibility: Communicating Information by Conformational Switching in Helical Oligomers

David T. J. Morris and Jonathan Clayden

Chem. Șoc. Rev. 2023, 52, 2480-2496 [doi 10.1039/D2CS00982J]

Screenshot 2023-03-09 at 08.57.56

313. Dynamic Kinetic Resolution and Dynamic Kinetic Asymmetric Transformation of Atropisomers

Jordan Berreur, Beatrice S. L. Collins and Jonathan Clayden

in Science of Synthesis: Dynamic Kinetic Resolution (DKR) and Dynamic Kinetic Asymmetric Transformations (DYKAT), Bäckvall, J.-E., Ed.; Thieme: Stuttgart (2023); Vol. 1, 441–483 [10.1055/sos-SD-237-00162]

311. Biocatalytic Enantioselective Synthesis of Atropisomers

Olivia F. B. Watts, Jordan Berreur, Beatrice S. L. Collins and Jonathan Clayden

Acc. Chem. Res. 2022, 55, 3362–3375 [10.1021/acs.accounts.2c00572]

Screenshot 2022-10-24 at 17.44.53

307. C(sp3)-Arylation by Conformationally Accelerated Intramolecular Nucleophilic Aromatic Substitution (SNAr)

Steven M. Wales, Rakesh K. Saunthwal and Jonathan Clayden

Acc. Chem. Res. 202255, 1731–1747 [doi 10.1021/acs.accounts.2c00184]

Screenshot 2022-05-27 at 10.45.38

251. Dynamic Foldamer Chemistry

Bryden A. F. le Bailly and Jonathan Clayden

Chem. Commun., in press [doi 10.1039/C6CC00788K]


234. Recent developments in inter- and intra-molecular enolate arylation

Fernando Fernández-Nieto and Jonathan Clayden

Reference Module in Chemistry, Molecular Sciences and Chemical Engineering (ed. J. Reedijk) Elsevier, Oxford  (ISBN 9780124095472) [doi 10.1016/B978-0-12-409547-2.11043-1]

219. Dearomatization and aryl migration in organolithium chemistry

Jonathan Clayden

in Lithium Compounds in Organic Synthesis, ed R. Luisi and V. Capriati, pub. Wiley-VCH 2014, chapter 13, pp. 375-394.

 187. The Urea Renaissance

Nicole Volz and Jonathan Clayden

Angew. Chemie Int. Ed. 201150, 12148-12155 [doi 10.1002/anie.201104037]


186. Dearomatizing reactions using organolithiums

Gilles Lemière and Jonathan Clayden

Science of Synthesis, Knowledge Updates 20114, 139-190.

180. Asymmetric synthesis of tertiary thiols and thioethers

Jonathan Clayden and Paul MacLellan

Beilstein J. Org. Chem20117, 582-595 [doi 10.3762/bjoc.7.68]


178. Quaternary centres bearing nitrogen (alpha-tertiary amines) as products of molecular rearrangements

Jonathan Clayden, Morgan Donnard, Julien Lefranc and Daniel J. Tetlow

Chem. Commun. 20114624-4639 [doi 10.1039/c1cc00049g]


159. The challenge of atropisomerism in drug discovery

Jonathan Clayden, Wesley J. Moran, Paul J. Edwards and Steven R. LaPlante

Angew. Chemie Int. Ed. 200948, 6398-6401 [doi 10.1002/anie.200901719]


150. Transmission of stereochemical information over nanometre distances in chemical reactions

Jonathan Clayden

Chem. Soc. Rev200938, 817-829 [doi 10.1039/b801639a]


137. Remote Control of Stereochemistry: Communicating Information via Conformation

Jonathan Clayden, in Molecular Interactions – Bringing Chemistry to Life , ed. M. G. Hicks and C. Kettner, pub. Beilstein Institut 2007, ISBN 978-3-8325-1791-5.

129. The twisted amide 2-quinuclidone: 60 years in the making

Jonathan Clayden and Wesley J. Moran

Angew. Chemie Int. Ed., 200645, 7118-7120 [doi 10.1002/anie.200603016]


125. Stereochemical relays: communication via conformation

Jonathan Clayden and Neoclis Vassiliou

Org. Biomol. Chem., 20064, 2667-2678 [doi 10.1039/b604548k]


109. Chemistry of domoic acid, isodomoic acids and their Analogues

Jonathan Clayden, Benjamin Read and Katherine R. Hebditch

Tetrahedron 200561, 5713-5724 [doi 10.1016/j.tet.2005.04.003]


103. Total synthesis of kainoids by dearomatizing anionic cyclisation

Jonathan Clayden

Strategies and Tactics in Organic Synthesis, vol. 4, p. 71. ed Michael Harmata, Academic Press, 2004

102. Cyclisations of organolithiums onto aromatic rings

Jonathan Clayden and Martin Kenworthy

Synthesis2004, 1721-1736 [doi 10.1055/s-2004-829138]

101. The directed metallation of aromatic compounds

Jonathan Clayden

in The Chemistry of Organolithium Compounds, pp 497-648, ed. Z. Rappoport and I. Marek, Wiley, Chichester, 2004

32. Stereocontrol with Rotationally Restricted Amides;

Jonathan Clayden, Synlett., 1998, 810-816

22. Non-Biaryl Atropisomers: New Classes of Chiral Reagents, Auxiliaries and Ligands?;

Jonathan Clayden, Angew. Chem., Int. Ed. Engl.199736, 949-951. (Nicht-Biaryl-Atropisomere: eine neue Klasse von chiralen Reagenten, Hilfsstoffen und Liganden?; Jonathan Clayden, Angew. Chem.1997109, 986-988)

18. Stereochemical Control in Organic Synthesis Using the Diphenylphosphinoyl (Ph2PO) Group;

Jonathan Clayden and Stuart Warren, Angew. Chem. Int. Ed. Engl.199635, 241-270 (Stereokontrolle in der organischen Synthese durch Verwendung der Diphenylphosphorylgruppe; Jonathan Clayden und Stuart Warren, Angew. Chem.1996108, 261)